University of California, San Diego
For each type of tumor, the extent of DE for GPCRs, determined via EdgeR. Included are fold changes and statistical significance in terms of False Discovery Rate (FDR).
DE of all GPCRs in each tumor type
Provides fold changes and statistical significance of changes in mRNA expression of all GPCRs in solid tumors (from TCGA) vs. corresponding normal tissue (from GTEx database).
In addition, these data are also available in Supplement 3.
Overexpressed GPCRs, including targets for approved drugs in each tumor type
GPCRs that show reduced expression in each tumor type
Changes in expression are considered meaningful if fold changes > 2 fold (increase or decrease), FDR < 0.05 and median expression in tumors > 1 TPM.