Welcome to the Insel Lab GPCRs in Cancer Resource

To cite this work, please refer to:

Sriram, K., Moyung, K., Corriden, R., Carter, H., & Insel, P. A. (2019). GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors. PLoS biology, 17(11).

PMC link to our article

Link to the article hosted at PLOS Biology

Access our preprint here.

This work is a secondary analysis based on the efforts of multiple groups, including: the UCSC Xena Project (https://xena.ucsc.edu), The Cancer Genome Atlas (TCGA, https://cancergenome.nih.gov/), The Genotype-Tissue Expression Database (GTEX, https://gtexportal.org/home/), and incorporating data on classification and characterization of GPCRs hosted by IUPHAR (Link).

If using data generated as part of this study, in addition to our paper, please cite the following soruces from which primary data were obtained:

• Vivian, J., Rao, A. A., Nothaft, F. A., Ketchum, C., Armstrong, J., Novak, A., … & Schmidt, H. (2017). Toil enables reproducible, open source, big biomedical data analyses. Nature Biotechnology, 35(4), 314.
• Consortium, T. G. (2013). The genotype-tissue expression (GTEx) project. Nature Genetics, 45(6), 580.

And acknowledge data generated by the TCGA Research Network: http://cancergenome.nih.gov/

If using any of our data on GPCR linkages and signal transduction, please also cite:

• Alexander, S. P., Davenport, A. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., … & Davies, J. A. (2015). The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors. British Journal of Pharmacology, 172(24), 5744-5869.

In addition, data on GPCR expression in cancer cell lines were mined from the EBI expression atlas

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