UCSD Insel Lab

University of California, San Diego

Additional Analyses

GPCR coupling

The file below contains quantification of the number of GPCRs in each tissue type or tumor that couple to different classes of G-alpha G proteins. Also included are expression weighted quantifications of the same, plus the total number of GPCRs present at different expression thresholds.

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GPCR coupling worksheet

Use the link below to download a file into which you can paste a list of GPCRs and obtain quantifications of the number of those GPCRs that couple to each G-alpha G protein. Will also yield an expression-weighted version of this coupling calculation.

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Impact of GPCR expression on survival

Use the link below to download a file with the impact GPCRs have on survival, for a range of tumor types.

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The input metadata and GPCR expression in CPM used to computes these values, plus the R code to generate these survival results, can be found here:

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Phylogenetic trees

From figure 4 of our updated manuscript, a phylogenetic fan plot showing different clusters of GPCRs in solid tumors, based on their median expression in TPM in each of 45 tumor types/subtypes.

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From figure S2, a phylogenetic fan plot showing different clusters of GPCRs in solid tumors, based on their fold change over corresponding normal tissue, in each of 45 tumor types/subtypes.

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STRING network figure 6A from our manuscript

Download a high-res version of the figure in a pwerpoint slide using the link below.

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